Pengaruh Konsentrasi Larutan Kitosan dan Volume Cross-linker Terhadap Kinetika Release Mikrokapsul Oleoresin Jahe Merah Dalam Medium Simulated Intestinal Fluid (SIF)

Jayanudin Jayanudin, Moh. Fahrurrozi, Sang Kompiang Wirawan, Rochmadi Rochmadi

Abstract


Oleoresin  jahe  merah  mengandung  komponen  yang  dapat  digunakan  sebagai antioksidan.  Studi  kinetika  release  digunakan  untuk  menyediakan  dosis  untuk pencapaian konsentrasi  obat  yang  sesuai.  Tujuan  penelitian  ini  adalah menentukan kinetika  release mikrokapsul  oleoresin  jahe  berdasarkan  perubahan  konsentrasi  kitosan  dan volume  agen crosslink dan menentukan koefisien difusi oleoresin jahe merah melalui dinding mikrokapsul. Mikrokapsul  oleoresin  jahe  merah  dipreparasi  dari  campuran  oleoresin  jahe merah  dalam larutan  kitosan  dan  diaduk  untuk  membentuk  emulsi.  seteleh  itu  ditambahkan ke  minyak jagung dan diaduk kembali untuk membentuk emulsi kedua. Glutaraldehyde saturated toluene diteteskan  sedikit  demi  sedikit  setelah  selesai  ditambahkan  25%  larutan glutaraldehida  dan tetap diaduk selama 2 jam. Mikrokapsul oleoresin jahe merah dipisahkan dan dicuci dengan petroleoum  eter  dan  heksan,  kemudian  dikeringkan  dalam  oven.  Mikrokapsul di  masukkan dalam medium release yaitu simulated intestinal fluid tanpa enzim kemudian sampel dianalisis menggunakan spektrofotometer UV-vis untuk mengetahui absorbansinya. Nilai koefisien relasi (R2 )  tertinggi  didapat  dari  model  kinetika  release  Korsmeyer-Peppas  yaitu R2   =  0.73-0.85 dengan nilai n = 0.39-0.41. Berdasarkan nilai n tersebut mekanisme release dari mikrokapsul oleoresin jahe merah adalah secara Fickian. Koefisien difusi yang dihasilkan yaitu 2.807 x 10-13 - 3.675 x 10 -13  cm 2 /detik.

Keywords


kinetika release, kitosan, oleoresin jahe merah, stimulated intestinal fluid

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References


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DOI: https://doi.org/10.31315/e.v16i2.3088

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